Fracture behavior of multilayer fibrous scaffolds featuring microstructural gradients

Gradients with depth in electrospun fibrous scaffolds for directed cell behavior.

A major obstacle in creating viable tissue-engineered constructs using electrospinning is the lack of complete cellularization and vascularization due to the limited porosity in these densely packed fibrous scaffolds. One potential approach to circumvent this issue is the use of various gradients of chemical and biophysical cues to drive the infiltration of cells into these structures. Toward t...

FRACTURE BEHAVIOR OF A Si3N4-BN FIBROUS MONOLITH CERAMIC

Electrospinning of photocrosslinked and degradable fibrous scaffolds.

Electrospun fibrous scaffolds are being developed for the engineering of numerous tissues. Advantages of electrospun scaffolds include the similarity in fiber diameter to elements of the native extracellular matrix and the ability to align fibers within the scaffold to control and direct cellular interactions and matrix deposition. To further expand the range of properties available in fibrous ...

Hierarchically engineered fibrous scaffolds for bone regeneration.

Surface properties of biomaterials play a major role in the governing of cell functionalities. It is well known that mechanical, chemical and nanotopographic cues, for example, influence cell proliferation and differentiation. Here, we present a novel coating protocol to produce hierarchically engineered fibrous scaffolds with tailorable surface characteristics, which mimic bone extracellular m...

Microstructural effects on the permeability of periodic fibrous porous media

An analytical-numerical approach is presented for computing the macroscopic permeability of fibrous porous media taking into account their micro-structure. A finite element (FE) based model for viscous, incompressible flow through a regular array of cylinders/fibers is employed for predicting the permeability associated with this type of media. High resolution data, obtained from our simulation...